By Frederick S. Fein (auth.), John C. Chatham D.Phil., John R. Forder Ph.D., John H. McNeill Ph.D. (eds.)
Diabetes is an enormous public sickness that is anticipated to impact a hundred and sixty million humans around the world through the 12 months 2000. sincerely an realizing of the results of diabetes at the center is a vital step within the improvement of concepts to lessen the prevalence of middle affliction for diabetic sufferers, therefore expanding their total life-expectancy and caliber of existence.
during this e-book, the editors collect the various strains of facts supportive of the assumption of a diabetic cardiomyopathy. the 1st bankruptcy offers an outline of the effect of cardiac disorder at the mortality and morbidity of the diabetic inhabitants generally, in addition to a presentation of medical elements of center sickness in diabetes. this is often by means of chapters serious about the pathological and practical adjustments that ensue within the center because of diabetes and an outline of a few of the healing interventions which are on hand to opposite the consequences of diabetes at the middle. next chapters specialise in adjustments in protein synthesis, membrane functionality and middleman metabolism that happen following the onset of diabetes. given that those adjustments precede the various useful and pathological alterations, it can be that the strategies answerable for the useful decline and tissue damage are initiated by means of diabetes-induced adjustments on the mobile and/or biochemical level.
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Additional resources for The Heart in Diabetes
Role of diabetes mellitus in congestive heart failure The Framingham study. Am. J. Cardiol. 34: 29-38, 1974. 45. Factor SM, Minase T and Sonnenblick EH. Clinical and morphological features of human hypertensive-diabetic cardiomyopathy. Am. Heart J. 99: 446-458, 1980. 46. Van Hoeven KH and Factor SM. A comparison of the pathological spectrum of hypertensive, diabetic, and hypertensive-diabetic heart disease. Circulation 82: 848-855, 1990. 47. Fein FS, Cho S, Zola BE, Miller B and Factor SM. Cardiac pathology in the hypertensive diabetic rat.
To assess the possible influence of exercise training on myocardial collagen, groups of exercised and nonexercised controls and alloxan induced diabetic dogs were formed. The concentrations of collagen in the left and right ventricles as well as septum were significantly increased in the non-exercised diabetics. Similar increments were not observed in the exercised diabetics in which the collagen concentrations approximated the normal control level . Since growth hormone has been considered a potential basis for enhanced collagen synthesis, the relation of plasma levels of growth hormone to collagen accumulation was examined .
Lyons TJ. Lipoprotein glycation and its metabolic consequences. Diabetes 41(SuppI2): 67-73, 1992. 35. Virella MF and Virella G. Immune mechanisms of atherosclerosis in diabetes mellitus. Diabetes 41(Suppl 2): 8691, 1992. 36. Jaffe AS, Spadaro JJ, Schectman K, Roberts R, Geltman EM and Sobel BE. Increased congestive heart failure after myocardial infarction of modest extant in patients with diabetes mellitus. Am. Heart. J. 108: 31-36, 1984. 37. Drury PL. Diabetes and arterial hypertension. Diabetologia 24: 1-9, 1983.