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Download Systems biology : mathematical modeling and model analysis by Andreas Kremling PDF

By Andreas Kremling

Basics advent organic BasicsThe Cell-an creation mobile department and development fundamentals of MetabolismReplication, Transcription, and TranslationFundamentals of Mathematical Modeling Definition-Overview of other version sessions fundamentals of response Engineering Stochastic Description Deterministic Modeling Qualitative Modeling and AnalysisModeling at the point of unmarried Cells-the inhabitants Balance Read more...

summary: basics creation organic BasicsThe Cell-an creation mobilephone department and development fundamentals of MetabolismReplication, Transcription, and TranslationFundamentals of Mathematical Modeling Definition-Overview of other version periods fundamentals of response Engineering Stochastic Description Deterministic Modeling Qualitative Modeling and AnalysisModeling at the point of unmarried Cells-the inhabitants stability Data-Driven Modeling ThermodynamicsModel Calibration and Experimental layout RegressionModel and Parameter AccuracyDynamic SystemsIdentifiability of Dynamic SystemsModeling of mobile seasoned

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The RNA-polymerase binds to the lac-promoter, which is located upstream of the genes lacZ, lacY and lacA. These three genes are transcribed into one RNA transcript and therefore build an operon, the lac operon. The first step of transcription, the binding of the RNA-polymerase to the promoter region, is called initiation. The initiation is followed by the elongation, the process in which the RNA-polymerase moves down the DNA chain and the mRNA transcript is formed. When a termination site is reached, it dissociates from the DNA and the mRNA is released.

The 5’-end is the end of the polynucleotide strand to which the phosphate molecule is bound to the C5 atom of the sugar molecule, and the 3’-end is the side without phosphate. The information for the encoded protein is stored in the sequence of the DNA bases. The protein itself is built by a sequence of amino acids. Each amino acid (protein building block) is encoded on the chromosome by a base triplet (codon), a sequence of three bases. During cell division, the DNA has to be copied. This results in two identical daughter chromosomes, which are passed to the daughter cells, so that in the end two genetically identical cells arise, which are called clones.

The enzymes themselves are not consumed during the chemical conversion and are therefore available for further reactions. Enzymes form a specific class of proteins. Generally they consist of different functional domains and catalyze one specific reaction, which means the conversion of one metabolite into another. First, the enzyme has to recognize the respective metabolite and subsequently it catalyzes the reaction. The participation of enzymes in reactions makes them controllable. However, only the velocity of the reaction can be modified, not the equilibrium.

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