Home Crop Science • Download Neurons and the DHA Principle by Raymond C. Valentine, David L. Valentine PDF

Download Neurons and the DHA Principle by Raymond C. Valentine, David L. Valentine PDF

By Raymond C. Valentine, David L. Valentine

Studies with micro organism and different structures recommend that the omega-3 fatty acid DHA confers nice advantages to neurons in maximizing either velocity of neural impulses and effort potency. regrettably, reports additionally express that DHA’s ease of oxidation damages membrane integrity. Exploring this duality, Neurons and the DHA Principle proposes a brand new version for the reasons of neurodegeneration, during which DHA-enriched membranes of neurons turn into dysfunctional and energetically wasteful, triggering the untimely demise of neurons.

The problem of this e-book is to digest how DHA acts as an important construction block of neurons whereas additionally conspiring for his or her assassination in the course of getting older. because the e-book studies the extreme houses of DHA in lifestyles varieties from deep-sea micro organism to human neurons, it asks:

  • Is there a trade-off among velocity and potency of mind functionality enabled via DHA as opposed to durability or lifestyles span?
  • Has smooth medication complex considerably within the remedy of the physique yet no longer inevitably of the brain?
  • What are the molecular reasons for the decline in mind healthiness through the age of longevity?

A complete accounting of the jobs of DHA in neurons calls for balancing the big merits of those molecules opposed to the hazards. Introducing the twin chemical personalities of DHA from an evolutionary point of view, Neurons and the DHA Principle explores DHA from the point of view of benefit–risk research, commencing new views for realizing how DHA services in neurons.

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R. Barhoumi, R. B. Tjalkens et al. 2005. The role of docosahexaenoic acid in mediating mitochondrial membrane lipid oxidation and apoptosis in colonocytes. Carcinogenesis 26:1914–1921. , N. Basilico, and M. Folinietal. 1998. Macrophage populations of different origins have distinct susceptibilities to lipid peroxidation induced by beta-haematin (malaria pigment). FEBS Lett. 433:215–218. , and B. Zhivotovsky. 2005. Cardiolipin oxidation sets cytochrome c free. Nat. Chem. Biol. 1:188–189. O’Shea, K.

Uptake of DHA is believed to prevent colon cancer. It is estimated that 70 percent of colorectal cancers are preventable by moderate changes in diet. Epidemiological studies indicate that populations ingesting higher amounts of fish are at a lower risk for colon cancer and a lower mortality rate of colorectal cancer, compared to those with diets high in saturated fat. , 2008). Colon cancer is a major killer triggered by mutations that upset the normal life and death cycle of colonic cells. It is not surprising that colon cancer cells have mutations that allow them to escape from undergoing programmed cellular death, a natural form of cellular suicide.

Billman, G. , Y. Nishijima, and A. E. Belevychetal. 2010. Effects of dietary omega-3 fatty acids on ventricular function in dogs with healed myocardial infarctions: In vivo and in vitro studies. Am. J. Physiol. Heart Circ. Physiol. 298:H1219–H1228. Bourre, J. M. 2006. Effects of nutrients (in food) on the structure and function of the nervous system: Update on dietary requirements for brain. Part 2: Macronutrients. J. Nutr. Health Aging10:386–399. Burr, G. , and M. M. Burr. 1929. A new deficiency disease produced by the rigid exclusion of fat from the diet.

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