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Download Metabolic Activation and Toxicity of Chemical Agents to Lung by T.E. Gram (Eds.) PDF

By T.E. Gram (Eds.)

Learn has proven that the lung is able to metabolically activating xenobiotics into intermediates that may covalently bind to pulmonary tissue. extra, it's been proven that the lung includes many unique mobile forms having the ability to take in and sequester metabolically unchanged medicines and chemical compounds which are eventually poisonous in influence. This quantity displays the level of those advancements and offers a state-of-the artwork reference in a speedily evolving box incorporating either drug metabolism and pulmonary toxicology learn

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Extra resources for Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells

Example text

5. 7-ETHOXYRESORUFIN O-DEETHYLATION 7-Ethoxyresorufin (7-ERF) O-deethylation, an activity mediated in rabbit lung solely by cytochrome P-450 isozyme 6, has been examined using microsomal preparations of isolated pulmonary cells from untreated as well as TCDD-treated rabbits. Very low activities were detected in Clara cells, type II cells and macrophages from untreated rabbits (Table 4). Following TCDD-treatment, 7-ERF deethylation increased about 20fold in Clara cells and type II cells and over 60-fold in macrophages.

D . (1979) Biochemical evidence for internal proteolytic damage during isolation of type II alveolar epithelial cells. Lung 1 5 6 : 243-254. FISHER, A . B . , HUBER, G . A . and FURIA, L . (1977) Cytochrome P-450 content and mixed-function oxidation by microsomes from rabbit alveolar macrophages. / . Lab. Clin. Med. 9 0 : 101-108. FoNG, A . T. and RASMUSSEN, R . E . (1987) Formation and accumulation of O^-ethylguanine in D N A of enriched populations of Clara cells, alveolar type II cells, and macrophages of hamsters exposed to diethylnitrosamines.

3 0 : 1 2 3 1 - 1 2 3 7 . DEVEREUX, T . R . , HOOK, G . E . R . and FOUTS, J . R . (1979) Foreign compound metabolism isolated cells from rabbit lung. Drug Metab. Disp. 7 : 70-75. DEVEREUX, T . R . , JONES, K . G . , B E N D , J . R . , F O U T S , J . R . , STATHAM, C . N . and B O Y D , M . R . (1981a) In vitro activation of the pulmonary toxin, 4-ipomeanol, in noncilicated bronchiolar epithelial (Clara) and alveolar type II cells isolated from rabbit. 7. Pharmac. Exp. Ther. 2 2 0 : 223-227. DEVEREUX, T .

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