Home Chemical • Download Metabolic Activation and Toxicity of Chemical Agents to Lung by T.E. Gram (Eds.) PDF

Download Metabolic Activation and Toxicity of Chemical Agents to Lung by T.E. Gram (Eds.) PDF

By T.E. Gram (Eds.)

Learn has proven that the lung is able to metabolically activating xenobiotics into intermediates that may covalently bind to pulmonary tissue. extra, it's been proven that the lung includes many unique mobile forms having the ability to take in and sequester metabolically unchanged medicines and chemical compounds which are eventually poisonous in influence. This quantity displays the level of those advancements and offers a state-of-the artwork reference in a speedily evolving box incorporating either drug metabolism and pulmonary toxicology learn

Show description

Read Online or Download Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells PDF

Best chemical books

The King Tiger: Development, Units, Operations

This can be the second one quantity protecting the use and variations of the King Tiger, in either photos and textual content.

Rock minerals, their chemical and physical characters and their determination in thin sections

This paintings has been chosen through students as being culturally very important, and is a part of the information base of civilization as we all know it. This paintings was once reproduced from the unique artifact, and is still as actual to the unique paintings as attainable. hence, you can find the unique copyright references, library stamps (as almost all these works were housed in our most vital libraries round the world), and different notations within the paintings.

Chemical Vapor Deposition Polymerization: The Growth and Properties of Parylene Thin Films

Chemical Vapor Deposition Polymerization - the expansion and houses of Parylene skinny movies is meant to be invaluable to either clients and researchers of parylene skinny movies. it's going to be really worthy for these developing and characterizing their first examine deposition procedure. It presents an excellent photograph of the deposition procedure and gear, in addition to details on system-to-system diversifications that's very important to contemplate while designing a deposition approach or making variations to an current one.

Catalysts for Fine Chemical Synthesis: Metal Catalysed Carbon-Carbon Bond-Forming Reactions, Volume 3

The chemist has an enormous variety of high-tech catalysts to take advantage of while operating in fine chemical synthesis however the catalysts are regularly not easy to take advantage of and require either time, ability and event to address accurately. The Catalysts for tremendous Chemical Synthesis series contains established and established systems which provide a distinct variety assets for chemists who paintings in natural chemistry.

Extra resources for Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells

Example text

5. 7-ETHOXYRESORUFIN O-DEETHYLATION 7-Ethoxyresorufin (7-ERF) O-deethylation, an activity mediated in rabbit lung solely by cytochrome P-450 isozyme 6, has been examined using microsomal preparations of isolated pulmonary cells from untreated as well as TCDD-treated rabbits. Very low activities were detected in Clara cells, type II cells and macrophages from untreated rabbits (Table 4). Following TCDD-treatment, 7-ERF deethylation increased about 20fold in Clara cells and type II cells and over 60-fold in macrophages.

D . (1979) Biochemical evidence for internal proteolytic damage during isolation of type II alveolar epithelial cells. Lung 1 5 6 : 243-254. FISHER, A . B . , HUBER, G . A . and FURIA, L . (1977) Cytochrome P-450 content and mixed-function oxidation by microsomes from rabbit alveolar macrophages. / . Lab. Clin. Med. 9 0 : 101-108. FoNG, A . T. and RASMUSSEN, R . E . (1987) Formation and accumulation of O^-ethylguanine in D N A of enriched populations of Clara cells, alveolar type II cells, and macrophages of hamsters exposed to diethylnitrosamines.

3 0 : 1 2 3 1 - 1 2 3 7 . DEVEREUX, T . R . , HOOK, G . E . R . and FOUTS, J . R . (1979) Foreign compound metabolism isolated cells from rabbit lung. Drug Metab. Disp. 7 : 70-75. DEVEREUX, T . R . , JONES, K . G . , B E N D , J . R . , F O U T S , J . R . , STATHAM, C . N . and B O Y D , M . R . (1981a) In vitro activation of the pulmonary toxin, 4-ipomeanol, in noncilicated bronchiolar epithelial (Clara) and alveolar type II cells isolated from rabbit. 7. Pharmac. Exp. Ther. 2 2 0 : 223-227. DEVEREUX, T .

Download PDF sample

Rated 4.99 of 5 – based on 12 votes