By Philip L. Fuchs
During the last 3 a long time the significance of organosilicon chemistry has tremendously elevated since it has opened a few new man made thoughts. Silicon reagents are typically reasonably cheap, flexible and make allowance quite a lot of reactions. this can be the 1st guide to bring together crucial Silicon containing reagents and uses the major reagent database e-EROS. one other scorching quantity within the sequence Handbooks of Reagents for natural Synthesis, it is a must-have source for all artificial chemists operating in drug improvement and medicinal chemistry.
For the choice the Editor focussed on 3 key man made methods with the best impact:
1. Use of silicon as a 'temporary tether' via unifying a reactive pair of useful teams and profiting from their template-biased intramolecular cyclization.
2. the categorical use of the silane performance as a hetero t-butyl workforce, usually colloquially known as using silicon as a 'fat proton'.
3. using the Brook rearrangement as an 'anion relay stratagem'.
A new characteristic during this guide is the reagent finder, an alphabetically geared up search for desk prepared by way of natural performance and particular constitution of the silicon atom to which it truly is certain.
Read or Download Handbook of Reagents for Organic Synthesis, Reagents for Silicon-Mediated Organic Synthesis PDF
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Additional info for Handbook of Reagents for Organic Synthesis, Reagents for Silicon-Mediated Organic Synthesis
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