Home Health Safety • Download Environmental Factors in Neurodevelopmental and by Michael Aschner PhD, Lucio G. Costa PhD PDF

Download Environmental Factors in Neurodevelopmental and by Michael Aschner PhD, Lucio G. Costa PhD PDF

By Michael Aschner PhD, Lucio G. Costa PhD

Environmental components in Neurodevelopmental and Neurodegenerative Disorders provides a state of the art assessment of the results of environmental contaminants at the improvement and degeneration of the human apprehensive approach, introduced jointly by way of world-leading specialists within the field.

Part One describes the hostile results that the surroundings could have on neurological improvement, and the way those results could show. particular contaminants and their attainable outcomes of publicity are addressed (lead, methylmercury, alcohol), in addition to particular problems and the environmental elements linked to them, equivalent to the impact of nutrition on recognition deficit and hyperactivity issues. half tackles neurodegenerative problems, in particular addressing their power neurotoxic origins, and discussing the expanding curiosity within the results that early publicity could have in later life.

Environmental elements in Neurodevelopmental and Neurodegenerative Disorders is a useful reference for these execs operating within the fields of toxicology, environmental health and wellbeing and neuroscience.

  • Provides, for the 1st time, the state-of-the-art idea of environmental affects on either neurodegenerative and neurodevelopmental disorders
  • Written via a global number of the world’s optimal specialists within the box of neurotoxicology
  • Full-colour all through, offering actual and illustrative examples of neurotoxic results in action
  • An valuable reference for these execs operating within the fields of toxicology, environmental well-being, and neuroscience

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Additional resources for Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders

Example text

Increased exposures to metals may play a role in AD and other neurodegenerative diseases, but given how tightly regulated metal ion concentrations are in the brain, increased exposure by a single source alone, such as dietary consumption (the main method of metal exposure), is highly unlikely. Summary The role of gene–environment interactions in AD is still being uncovered. Although a great wealth of information is available relating to purely inherited, early-onset AD, the combination of events leading to the development of sporadic AD is still quite unknown.

In fact, epidemiological evidence suggests that veterans of the Gulf War exposed to BMAA have increased prevalence of ALS, though these reports are controversial [73,74]. To date, no known genetic susceptibility to neurotoxicity induced by BMAA exists. I. NEURODEVELOPMENTAL DISORDERS 32 2. GENETIC FACTORS IN ENVIRONMENTALLY INDUCED DISEASE Recent evidence suggests that apolipoprotein E (ApoE) may play a role in BMAA distribution and metabolism, as animal models have shown that BMAA toxicity is partially regulated by ApoE variants [75].

J Neurochem 1994;62(1):384–7. [44] Turner BJ, Talbot K. Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS. Prog Neurobiol 2008;85(1):94–134. [45] Bruijn L, Becher M, Lee M, Anderson K, Jenkins N, Copeland N, et al. ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron 1997;18(2):327–38. [46] Kikuchi H, Almer G, Yamashita S, Guégan C, Nagai M, Xu Z, et al. Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model.

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