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Download Endocrine Disrupting Chemicals (Issues in Environmental by R.E. Hester, R.M. Harrison PDF

By R.E. Hester, R.M. Harrison

Experiences the clinical proof and makes an attempt to place the topic into context. provides a multidisciplinary strategy. Softcover.

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Extra resources for Endocrine Disrupting Chemicals (Issues in Environmental Science and Technology)

Example text

Hatching failure can be due to a multiplicity of causes, but some syndromes of abnormality such as blue-sac disease and the similar PCB-induced M74 syndrome affecting Baltic salmon appear to be surprisingly common, which suggests disruption of key stages of embryonic or larval development. Until the site of action involved can be clarified, and whether the xenobiotic acts via hormonal or cellular signalling can be determined, it must remain open as to whether this can truly be called endocrine disruption.

Endocrine dysfunction in fish from such areas has been demonstrated, but cannot simply be causally related to the high levels of these particular chemicals since they are inevitably associated with many of the hundreds of thousands of other chemicals that are released from other industrial processes in the same waterways. Commercial secrecy is a major impediment to identifying and restricting release of endocrine disrupting chemicals. The scale of the problem is exemplified by pesticide formulations in which the active ingredient is mixed with an ‘inert dispersant’.

In addition, there are some endocrine functions that are far more easily investigated in fish than in mammals. Recent reports in the popular press concentrating on the threat to male fertility posed by environmental estrogens have largely obscured both the fact that female fertility may be equally well compromised and that such effects can be caused by many compounds that are not estrogenic. Although such bias may be attributable to the need to make a good story, or to a male dominated society, they also reflect the fact that males continually produce sperm in extremely large amounts which are physically accessible for research.

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