Home Nonfiction 10 • Download Cutaneous Melanoma and Precursor Lesions by R. M. MacKie (auth.), Dirk J. Ruiter MD, Kees Welvaart MD, PDF

Download Cutaneous Melanoma and Precursor Lesions by R. M. MacKie (auth.), Dirk J. Ruiter MD, Kees Welvaart MD, PDF

By R. M. MacKie (auth.), Dirk J. Ruiter MD, Kees Welvaart MD, Soldano Ferrone MD (eds.)

In fresh years a lot growth has been made in wisdom and knowing of the biology of cutaneous cancer. during this appreciate etiological elements, prognostic components, antigen expression of cancer cells, immune reaction and mechanisms of metastasis formation must be pointed out. it's the function of this publication to provide a overview on primary facets, analysis and diagnosis, and therapy of cutaneous cancer and precursor lesions. furthermore, formerly unpublished new information are offered. A post-graduate Boerhaave direction "Cutaneous cancer and Precursor Lesions" used to be held at Leiden college on 12 and thirteen April,. 1984. The lawsuits are contained during this quantity. The editors want to thank all audio system and chairpersons at the direction, the Boerhaave Committee for its contribution to the employer of the direction, Upjohn Nederland for its monetary help and Mrs. I.A. Kruyff for her secretarial counsel. Dirk Ruiter, Kees Welvaart and Soldano Ferrone, Leiden and Valhalla (NY), June, 1984. VII CONTENTS Preface v Contents VII checklist of First Authors with Co-Authors XI half I: primary facets. The epidemiology of cancer R.M. MACKIE The molecular biology of carcinogenesis nine A.W.M. VAN DER KAMP AND N.G.J. JASPERS 19 Human cancer linked antigens pointed out with monoclonal antibodies: characterization and capability medical program P.G. NATALI, R. CAVLIERE, M. MATSUI, G. BURAGGI, L. CALLEGARO, and S. FERRONE mobile and molecular parameters of tumor development in 38 human malignant cancer J. BRUEGGEN, E.B. BROECKER, L. SUTER, okay. REDMANN, and C.

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Iv There are marked differences in the distribution of radioactivity and its clearance in the patients investigated. Representative examples are shown in figure 5. The mechanism(s) underlying this variability is not known. 0 Q / 1 0 o BE 18 QVG 16 0 0 cr -0 c: ::::l 0 .... : u 0 en '- .... 0 E ::::l I- o GG8 o~ODL6 o L-_ _ _ _ _ _ _I . 285. applied for in-vitro and markers likely to be also useful targets to test the usefulness of are in-vivo 2 immunodiagnostic approaches. These immunotherapeutic approaches to melanoma.

1981. Expression of surface antigens and its relation to parameters of malignancy in human malignant melanoma. Cancer Immunol lmmunother 10: 121. 8. -B. 1983. Monoclonal antibodies against human malignant melanoma. Bull Cancer 70: 113 9. Natali PG, Aguzzi A, Veglia F, Imai K, Burlage RS, Giacomini P, Ferrone S. 1983. The impact of monoclonal antibodies on the study of human malignant melanoma. J Cutan Path 10: 514 10. Dexter DL, Calabresi P, 1982. Intraneoplastic diversity. Biochem Biophys Acta 695: 97 11.

In this context it seems of interest that other authors have found a metastasizing capacity in the nude mouse for A-375 (26). A-375 and MeWo show also a hypomethylation pattern of DNA, which seems to be characteristic for malignant cells (27). The finding that a melanoma line, which is less malignant, contains subclones, which have a higher degree of malignancy reflects the in vivo situation where melanomas reveal a heterogeneity not only with regard to growth characteristics, but also to pigmentation, morphology and antigenic expression (5,7,28).

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