By Ronald G. Harvey (auth.), Trevor M. Penning (eds.)
This monograph offers a latest account of advances in chemical carcinogenesis. It promotes the view that it truly is alteration of the DNA through endogenous and exogenous cancer agents that finally results in sporadic mutations that are a root explanation for many human cancers. It bargains with the metabolic activation of universal sessions of chemical cancer agents (tobacco cancer causing agents, heterocyclic amines, polycyclic fragrant hydrocarbons) and their detoxication. It describes the DNA-adducts that occur and their fix mechanisms. It covers advances in structural-biology that supply a glimpse of either the DNA-repair procedure and the by-pass of DNA-lesions and the way this informs the mutational code. It additionally bargains with the recommendations of chemoprevention and biomarkers for biomonitoring human publicity. Many modern texts at the biology of melanoma now concentration nearly solely at the molecular and cellphone biology of the disorder and don't conceal the starting up (DNA destructive occasions) of chemical carcinogenesis extensive. it's with this perceived gap-in wisdom that global specialists of their specific fields have contributed to this monograph. This monograph can be an immense reference re-source for college students in education, postdoctoral scientists, and senior scientists an expert within the field.
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Additional resources for Chemical Carcinogenesis
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