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Download Biological Reactive Intermediates—II: Chemical Mechanisms by Robert Snyder PDF

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USA, 76:5929. O'Gorman, T. and La Mont, J. , 38:2784. Parke, D. W. , Plenum, London. Parke, D. , 1980, The role of the endoplasmic reticulum, in: "Concepts in Drug Metabolism - 2", P. Jenner and B. , Marcel Dekker, New York. V. 335-346, in: "Primary Liver Tumours", H. M. Boll, P. Bannasch and H. , MTP Press, Lancaster. V. , 1977, The biochemical pharmacology of mucus, in: "Mucus in Health and Disease", M. Elstein and D. V. , Plenum, New York. 38 D. PARKE AND C. , 1980, Redox cycle of stable mixed nilroxides formed from carcinogenic aromatic amines, Xenobiolica, in press.

These compounds (16) and (17) are non-mutagenic in agreement with these structura~propertTes. For the oxiranes which are not activated by a double bond, an inverse correlation is found between mutagenicity and the number of epoxide rings within the molecule. The mutagenic activity decreased in the following order: cyclohexene oxide (1) > cyclohexa1 ,3-diene dioxide (6) ~ cyclohexa-1 ,4-diene dioxide-(5) > transbenzene trioxide (9T >cis-benzene trioxide (10). The latter compound was not mutagenic at all.

Emmelot and E. , p. 25, Elsevier/North Holland Biomedical Press, Amsterdam. Miller, J. , Swanson, A. , and Miller, E. , 1979, The metabolic activation of safrole and related naturally occurring alkenylbenzenes in relation to carcinogenesis by these agents, in: "Naturally Occurring Carcinogens-lliutagens and Modulators of Carcinogenesis," E. c. Miller, J. A. Miller, I. Hirano, T. Sugimura, and s. , p. 111, Japan Scientific Societies Press, Tokyo. , 1978, Genetic mosaicism and in vivo analyses of neoplasia and differentiation, in: "Cell Differentaition and Neoplasia," G.

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